Effect of chronic ethanol ingestion on fatty acid oxidation by hepatic mitochondria.

Effect of chronic ethanol ingestion on fatty acid oxidation by hepatic mitochondria.

To study possible factors in the pathogenesis of the ethanol-induced fatty liver, we investigated the effect of chronic ethanol consumption on the metabolism of fatty acids by isolated hepatic mitochondria. Chronic ethanol consumption resulted in decreased fatty acid oxidation, as evidenced by a reduction in oxygen uptake and CO2 production associated with the oxidation of fatty acids. The Stat...

The effect of ethanol on fatty acid metabolism; stimulation of hepatic fatty acid synthesis in vitro.

Adaptive Changes Induced by Chronic Ethanol Ingestion on Hepatic Mitochondrial and Microsomal Enzyme Activities

Ethanol exerts its pbarmacologlcal effects by alteriag the pkysico-ckemical propeof biological membranes. Modlflcatlons induced by ethanol may reta& in ckangeg lo the activity of membtane-boand enzymes tkat have been shown to reqdre a speclflc membram? flnldlty and composition for optimal function. In tbll study we have carried oat the analysis of the effects of ethanol on the different enzyme ...

Effect of colostrum intake on hepatic gluconeogenesis and fatty acid oxidation in the neonatal pig.

A total of 24 newborn pigs were used to determine 1) the relationship between the quantity of colostrum consumed and the capacity for gluconeogenesis and fatty acid oxidation and 2) whether fatty acid oxidation limits gluconeogenesis in isolated hepatocytes. Neonatal pigs were obtained prior to nursing and allotted to one of three treatment groups; fed (ad libitum), limit-fed (25% of fed group)...

Regulation of hepatic fatty acid oxidation and ketogenesis.